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677520  Virstatin

4-(N-(1,8-Naphthalimide))-n-butyric acid

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26 May 2012

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This product has been discontinued.

Please refer to our complete listing of antimicrobial agents for possible alternatives. Please read the alternative product documentation carefully and contact technical service if you need additional information.





A cell-permeable naphthalimide compound that inhibits virulence regulation in Vibrio cholerae. Shown to target the transcriptional regulator ToxT, block its dimerization, and prevent the expression of cholera toxin and the toxin coregulated pilus (TCP) with minimal bacterial toxicity. Effectively protects infant mice against TCP-dependent V. cholerae intestinal colonization in vivo. Displays little toxicity towards mammalian cells (up to 2mM for Hep2 cells).
Product information
Form Pale yellow solid
Molar mass 283.3
Protect from Light Yes
Packaged under inert gas Yes
Purity ≥97% by HPLC
Solubility DMSO
Chemical formula C16H13NO4
CAS number 88909-96-0
Store and ship information
Storage +2°C to +8°C
Ship Ambient Temperature Only
Harmful
Virstatin, molecular structure

© Merck KGaA, Darmstadt, Germany, 2012

All references to Merck refer to Merck KGaA, Darmstadt, Germany.


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