676501
VEGFR Tyrosine Kinase Inhibitor V
N-Cyclopropyl-6-(6,7-dimethoxyquinolin-4-yloxy)-1-naphthamide, HCl, VEGF Receptor Tyrosine Kinase Inhibitor V, VEGFR2 Kinase Inhibitor XXIII, VEGFR1 Kinase Inhibitor VI, VEGFR3 Kinase Inhibitor VI
For general questions please contact our Customer Service:
EMD Millipore
290 Concord Road
01821 Billerica, MA
United States
Phone: 781 533-6000
Fax: +49 6151 72 2000
E-mail: Customer.CareDesk@emdchemicals.com
26 May 2012
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A cell-permeable, ATP-binding pocket-targeting N-cyclopropylnaphthamide compound that acts as a potent inhibitor against VEGFR1/2/3 (IC50 = 0.6 nM against VEGFR2), c-FMS, RET, Lyn, and c-KIt, while exhibiting much reduced activity against 36 other commonly studied kinases. Selectively inhibits HUVEC proliferation induced by VEGF over bFGF (IC50 = 0.91 vs. 170 nM, respectively). It is orally active in mice and rats and is shown to effectively reduce VEGF-mediated vascular permeability and angiogenesis in vivo.
| Product information | |||
|---|---|---|---|
| Form | Beige solid | ||
| Molar mass | 468.9 | ||
| Protect from Light | Yes | ||
| Hygrocopic | Yes | ||
| Packaged under inert gas | Yes | ||
| Purity | ≥97% by HPLC | ||
| Solubility | DMSO or EtOH | ||
| Chemical formula | C25H22N2O4 • HCl • H2O | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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