662086
UCH-L1 Inhibitor
LDN-57444, Ubiquitin C-Terminal Hydrolase L1 Inhibitor, Ubiquitin C-Terminal Esterase L1 Inhibitor, Ubiquitin Thiolesterase L1 Inhibitor
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EMD Millipore
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01821 Billerica, MA
United States
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E-mail: Customer.CareDesk@emdchemicals.com
20 May 2013
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An isatin O-acyl oxime compound that acts as a potent, reversible, competitive, and active site-directed inhibitor of UCH-L1 (Ki = 0.40 µM; IC50 = 0.88 µM) with ~28-fold greater selectivity over UCH-L3 (Cat. No. 662090). Shown to increase proliferation of UCH-L1 expresssing tumor cell line SH-SY5Y at 5 µM. A useful tool for studying the roles of UCH-L1 in cancer, Parkinson’s disease, and other neurological disorders. Permeability may vary from cell type to cell type.
| Product information | |||
|---|---|---|---|
| Form | Orange solid | ||
| Primary Target | UCH-L1 | ||
| Primary Target IC50 | 0.88 µM | ||
| Molar mass | 397.6 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| Reversible | Yes | ||
| Purity | ≥95% by HPLC | ||
| Solubility | DMSO | ||
| Chemical formula | C17H11Cl3N2O3 | ||
| CAS number | 668467-91-2 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Carcinogenic / Teratogenic |
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