647925
Trichostatin A, Streptomyces sp.
4,6-Dimethyl-7-[p-dimethylaminophenyl]-7-oxahepta-2,4-dienohydroxamic Acid, TSA
For general questions please contact our Customer Service:
EMD Millipore
290 Concord Road
01821 Billerica, MA
United States
Phone: 781 533-6000
Fax: 800-645-5439
E-mail: Customer.CareDesk@emdchemicals.com
19 May 2013
loading
A potent and reversible, cell-permeable inhibitor of histone deacetylase. Blocks cell cycle progression at the G1 phase in HeLa cells and induces a 12-fold increase in intracellular levels of gelsolin. Induces reversion of oncogenic ras-transformed NIH/3T3 cells to a normal morphology. Inhibits IL-2 gene expression (IC50 = 73 nM) in Jurkat cells and shows immunosuppressive activity in a mouse model. Down-regulates p57kip2 in Hep 3B cells. A 10 mM (500 µg/165 µl) solution of Trichostatin A, Streptomyces sp. (Cat. No. 647926) in DMSO is also available.
| Product information | |||
|---|---|---|---|
| Form | Off-white lyophilized solid | ||
| Primary Target | histone deactylase | ||
| Secondary target | IL-2 gene expression (IC50 = 73 nM) | ||
| Molar mass | 302.4 | ||
| Cell permeable | Yes | ||
| Reversible | Yes | ||
| Purity | ≥98% by HPLC | ||
| Solubility | DMSO, EtOH, MeOH | ||
| Chemical formula | C17H22N2O3 | ||
| RTECS | MI5215000 | ||
| CAS number | 58880-19-6 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Ambient Temperature Only
Harmful |
||
| Safety information | |||
|---|---|---|---|
| S Phrase |
S: 26-36 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing. |
||
| R Phrase |
R: 20/21/22-36/37/38-43 Harmful by inhalation, in contact with skin and if swallowed. Irritating to eyes, respiratory system and skin. May cause sensitization by skin contact. |
||
