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573099  STAT3 Inhibitor V, Stattic

6-Nitrobenzo[b]thiophene-1,1-dioxide, Stat three inhibitory compound

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25 April 2014

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573099-25MG  25 mg 
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A cell-permeable vinyl-sulfone compound that acts as an inhibitor of STAT3 cellular function by targeting the STAT3-SH2 domain and preventing its association with upstream kinases. The effect of Stattic towards STAT family members is temperature-dependent and appears to be highly STAT3-selective at 37°C. Shown to inhibit cellular phosphorylation of STAT3 at Tyr705 with little effect towards STAT1 phosphorylation at Tyr701 (in HepG2 cells) or the phosphorylation of JAK1, JAK2, and c-Src (in MDA-MB-231 and MDA-MB-235S cells).
Product information
Form Pale yellow solid
Molar mass 211.2
Protect from Light Yes
Packaged under inert gas Yes
Purity ≥95% by HPLC
Solubility DMSO or EtOH
Chemical formula C8H5NO4S
CAS number 19983-44-9
Store and ship information
Storage +2°C to +8°C
Ship Ambient Temperature Only
Irritant
STAT3 Inhibitor V, Stattic, molecular structure

© Merck KGaA, Darmstadt, Germany, 2014

All references to Merck refer to Merck KGaA, Darmstadt, Germany.


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