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Reduces epirubicin-induced cell injury and caspase-3/7 activity. A highly specific, potent, cell-permeable, selective, reversible, and ATP-competitive inhibitor of p38 MAP kinase (IC
50 = 34 nM
in vitro, 600 nM in cells). Does not significantly inhibit the JNK and p42 MAP kinase at 100 µM. Inhibits IL-1 and TNF-α production from LPS-stimulated human monocytes and the human monocyte cell line THP-1 (IC
50 = 50-100 nM). Inhibits bone morphogenetic protein-2-induced neurite outgrowth in PC12 cells. Also inhibits platelet aggregation caused by collagen (IC
50 = 0.2-1.0 µM) or the thromboxane analog U-46619 (Cat. No.
538944). A 1 mg/ml solution of SB 203580 (Cat. No.
559398) in anhydrous DMSO is also available.
| Accesorios para SB 203580 |
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Información sobre producto
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Form
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Thin film
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Primary Target
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P38MAPK
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Primary Target IC50
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34 nM
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Secondary target
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THP-1 (IC50 = 500-100 nM)
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Masa molar
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377.4
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Protect from Light
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Si
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Cell permeable
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Si
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Purity
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≥98% by HPLC
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Solubilidad en agua
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DMSO
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Fórmula químico
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C21H16N3OSF
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Número CAS
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152121-47-6
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Almacenar y enviar información
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Categoría de alamacenamiento
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-20°C
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Ship
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Ambient Temperature Only
Irritant
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Información de seguridad
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Frase S
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S: 26-36-45
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Frase R
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R: 36/37/38
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