555554
Rho Kinase Inhibitor IV
(S)-(+)-2-Methyl-4-glycyl-1-(4-methylisoquinolinyl-5-sulfonyl)homopiperazine, 2HCl, H-1152, Glycyl
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EMD Millipore
290 Concord Road
01821 Billerica, MA
United States
Phone: 781 533-6000
Fax: +49 6151 72 2000
E-mail: Customer.CareDesk@emdchemicals.com
25 May 2012
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A cell-permeable, reversible, and ATP-comptetive glycyl analog of Rho-Kinase Inhibitor (Cat. No. 555550) that inhibits ROCK with an improved selectivity (IC50 = 11.8 nM, > 10 µM, > 10 µM, 3.26 µM, 2.35 µM, and 2.57 µM for ROCKII, PKA, PKC, PKG, Aurora A, and CaMKII, respectively).
| Product information | |||
|---|---|---|---|
| Form | Pale yellow solid | ||
| Primary Target | ROCK II | ||
| Primary Target IC50 | 11.8 nM | ||
| Secondary target | IC50 = 10 µM, >10 µM, 3.26 µM, 2.35 µM, and 2.57 µM for PKA, PKC, PKG, Aurora A, and CaMKII, respectively | ||
| Molar mass | 467.4 | ||
| Protect from Light | Yes | ||
| Hygrocopic | Yes | ||
| Packaged under inert gas | Yes | ||
| Purity | ≥98% by HPLC | ||
| Solubility | DMSO or H2O | ||
| Chemical formula | C18H24N4O3S • 2HCl • H2O | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Harmful |
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