539211
Protein Methyltransferase Inhibitor, AMI-5
Disodium-2-(2,4,5,7-tetrabromo-3-oxido-6-oxoxanthen-9-yl)benzoate, trihydrate, A(K)MI-5, PRMT Inhibitor III
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EMD Millipore
290 Concord Road
01821 Billerica, MA
United States
Phone: 781 533-6000
Fax: 800-645-5439
E-mail: Customer.CareDesk@emdchemicals.com
19 May 2013
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A xanthenyl compound that inhibits the activities of protein arginine methyltransferases (PRMT) Hmt1p, PRMT1/3/4/6 (IC50 against yeast Hmt1p & human PRMT1 = 0.78 and 1.41 µM, respectively), as well as histone lysine methyltransferases (HMTases) SET7 and DOT1 in an AdoMet/SAM- (S-adenosylmethionine) competitive manner. Although SAM-competitive inhibitors generally exhibit broad activity against and are non-selective toward most SAM-utilizing enzymes, AMI-5 is known to be inactive against at least two HMTases (Suv39H1 and Suv39H2).
| Product information | |||
|---|---|---|---|
| Form | Reddish brown solid | ||
| Molar mass | 745.9 | ||
| Protect from Light | Yes | ||
| Hygrocopic | Yes | ||
| Packaged under inert gas | Yes | ||
| Purity | ≥90% | ||
| Solubility | H2O | ||
| Chemical formula | C29H6Br4O5Na2 • 3H2O | ||
| CAS number | 17372-87-1 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Irritant |
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| Safety information | |||
|---|---|---|---|
| S Phrase |
S: 24/25-36/37/39-45 Avoid contact with skin and eyes. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). |
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| R Phrase |
R: 36/38 Irritating to eyes and skin. |
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