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539211  Protein Methyltransferase Inhibitor, AMI-5

Disodium-2-(2,4,5,7-tetrabromo-3-oxido-6-oxoxanthen-9-yl)benzoate, trihydrate, A(K)MI-5, PRMT Inhibitor III

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19 April 2014

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539211-50MG  50 mg 
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A xanthenyl compound that inhibits the activities of protein arginine methyltransferases (PRMT) Hmt1p, PRMT1/3/4/6 (IC50 against yeast Hmt1p & human PRMT1 = 0.78 and 1.41 µM, respectively), as well as histone lysine methyltransferases (HMTases) SET7 and DOT1 in an AdoMet/SAM- (S-adenosylmethionine) competitive manner. Although SAM-competitive inhibitors generally exhibit broad activity against and are non-selective toward most SAM-utilizing enzymes, AMI-5 is known to be inactive against at least two HMTases (Suv39H1 and Suv39H2).
Product information
Form Reddish brown solid
Molar mass 745.9
Protect from Light Yes
Hygrocopic Yes
Packaged under inert gas Yes
Purity ≥90%
Solubility H2O
Chemical formula C29H6Br4O5Na2 • 3H2O
CAS number 17372-87-1
Store and ship information
Storage +2°C to +8°C
Ship Ambient Temperature Only
Irritant
Safety information
S Phrase S: 24/25-36/37/39-45

Avoid contact with skin and eyes.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
R Phrase R: 36/38

Irritating to eyes and skin.
Protein Methyltransferase Inhibitor, AMI-5, molecular structure

© Merck KGaA, Darmstadt, Germany, 2014

All references to Merck refer to Merck KGaA, Darmstadt, Germany.


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