Pathways: Angiogenesis

Fibroblast Growth Factor (bFGF)

bFGF Antibodies

	Cat. No.	Product
[+]	PC15	Anti-FGF, Basic (Ab-1) (147-153) Rabbit pAb
[+]	PC16	Anti-FGF, Basic (Ab-2) (40-63) Rabbit pAb
[+]	GF22L	Anti-FGF, Basic (Ab-3) Mouse mAb (3H3)

bFGF Assay Kit

	Cat. No.	Product
[+]	QIA64	Human FGF, Basic ELISA Kit

bFGF Proteins/Enzymes

	Cat. No.	Product
[+]	341583	FGF-2, Basic, Bovine
[+]	341595	FGF-2, Basic, Human, Recombinant, E. coli

VEGF

VEGF Antibodies

	Cat. No.	Product
[+]	PC37	Anti-VEGF (Ab-2) Rabbit pAb
[+]	GF25	Anti-VEGF (Ab-3) Mouse mAb (14-124)
[+]	PC315	Anti-VEGF (Ab-4) Rabbit pAb
[+]	GF41	Anti-VEGF (Ab-5) Mouse mAb (JH121)
[+]	GF46	Anti-VEGF (Ab-6) Mouse mAb (VG76e)
[+]	PC322L	Anti-VEGFR1 Goat pAb
[+]	676488	Anti-VEGFR2 (931-997) Rabbit pAb
[+]	676486	Anti-VEGFR2 Mouse mAb (CH-11)
[+]	343009	Anti-VEGFR3 Rabbit pAb
[+]	PC459	PhosphoDetect™ Anti-VEGFR 1 (Ab-2) (pTyr¹2¹3) Rabbit pAb
[+]	PC460	PhosphoDetect™ Anti-VEGFR2/3 (pAb-1) Rabbit pAb
[+]	PS1013	PhosphoDetect™ Anti-VEGFR2 (pTyr1054/1059) Rabbit pAb
[+]	PS1012	PhosphoDetect™ Anti-VEGFR2 (pTyr¹2¹4) Rabbit pAb

VEGF Activators

	Cat. No.	Product
[+]	676491	VEGF Inducer, GS4012

VEGF Assay Kits & Tools

	Cat. No.	Product
[+]	676491	VEGF Inducer, GS4012

VEGF Inhibitors

	Cat. No.	Product
[+]	341607	FGF/VEGF Receptor Tyrosine Kinase Inhibitor, PD173074
[+]	676498	InSolution™ VEGFR2 Kinase Inhibitor III
[+]	676496	VEGF Inhibitor, CBO-P11
[+]	676493	VEGF Inhibitor, Flt2-11
[+]	676494	VEGF Inhibitor, Je-11
[+]	676495	VEGF Inhibitor, V1
[+]	676499	VEGFR 2/3 Kinase Inhibitor
[+]	676480	VEGFR2 Kinase Inhibitor I
[+]	676485	VEGFR2 Kinase Inhibitor II
[+]	676487	VEGFR2 Kinase Inhibitor III
[+]	676489	VEGFR2 Kinase Inhibitor IV
[+]	676484	VEGFR2 Kinase Inhibitor VI, Ki8751
[+]	676492	VEGFR3 Kinase Inhibitor, MAZ51
[+]	676481	VEGFR Tyrosine Kinase Inhibitor II
[+]	676482	VEGFR Tyrosine Kinase Inhibitor III, KRN633
[+]	676483	VEGFR Tyrosine Kinase Inhibitor IV

VEGF Proteins/Enzymes

	Cat. No.	Product
[+]	676473	VEGF121, Human, Recombinant, S. frugiperda
[+]	676474	VEGF164, Mouse, Recombinant, S. frugiperda
[+]	PF074	VEGF165, Human, Recombinant
[+]	676472	VEGF165, Human, Recombinant, S. frugiperda
[+]	676476	VEGF-C, Rat, Recombinant, S. frugiperda
[+]	325895	VEGFR1, GST-Fusion, Human, Recombinant, S. frugiperda
[+]	PF082	VEGFR1, Human, Recombinant, S. frugiperda
[+]	676490	VEGFR2D1-7, Human, Recombinant, S. frugiperda

Angiogenin Fibroblast Growth Factor (FGF)

Angiogenin Antibody

	Cat. No.	Product
[+]	175600	Angiogenin, Human, Recombinant, E. coli
[+]	PC317L	Anti-Angiogenin Goat pAb

Angiogenin Protein/Enzyme

	Cat. No.	Product
[+]	175600	Angiogenin, Human, Recombinant, E. coli

Transforming Growth Factor

TGF-b

	Cat. No.	Product
[+]	GF33L	Anti-TGF-β1 (Ab-1) Mouse mAb (9016.2)
[+]	GF16	Anti-TGF-β3 (Ab-1) Mouse mAb (236-5.2)
[+]	616450	TGF-β1, Human Platelets
[+]	616455	TGF-β1, Human, Recombinant, CHO Cell Line
[+]	616460	TGF-β1, Porcine Platelets
[+]	PF017	TGF-β2, Human, Recombinant, E. coli
[+]	PF073	TGF-β3, Human, Recombinant, S. frugiperda
[+]	616451	TGF-β RI Kinase Inhibitor
[+]	616452	TGF-β RI Kinase Inhibitor II
[+]	616453	TGF-β RI Kinase Inhibitor III

p53

p53 Antibodies

Connectivity	3212
Notes	Tumor protein p53, a nuclear protein, plays an essential role in the regulation of cell cycle, specifically in the transition from G0 to G1. It is found in very low levels in normal cells, however, in a variety of transformed cell lines, it is expressed in high amounts, and believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing DNA-binding, oligomerization and transcription activation domains. It is postulated to bind as a tetramer to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of the TP53 gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome.
Hugo ID	11998
Name	p53
Description	transformation related protein 53
URN	urn:agi-llid:7157

GO Cellular Component	cytoplasm
	cytosol
	nucleus
	mitochondrion
	nucleolus

Cell Localization	Nucleus

GO Biological Process	DNA damage response, signal transduction by p53 class mediator
	apoptosis
	negative regulation of cell cycle
	negative regulation of cell growth
	protein-nucleus import, translocation
	regulation of transcription from Pol II promoter
	regulation of transcription, DNA-dependent
	transcription
	DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
	cell cycle
	negative regulation of DNA replication
	negative regulation of apoptosis
	negative regulation of fibroblast proliferation
	regulation of cell proliferation
	response to DNA damage stimulus
	response to UV
	response to X-ray
	caspase activation via cytochrome c
	cell aging
	cell cycle arrest
	cell cycle checkpoint
	cell differentiation
	cell proliferation
	induction of apoptosis by hormones
	negative regulation of helicase activity
	nucleotide-excision repair
	regulation of mitochondrial membrane permeability

MGI ID	98834

Swiss-Prot Accession	P04637

OMIM ID
	OMIM:114480
	OMIM:114500
	OMIM:114550
	OMIM:151623
	OMIM:161550
	OMIM:260350

Alias	Tp53
	p53
	Trp53
	tumor protein p53 (Li-Fraumeni syndrome)
	transformation related protein 53
	P53_HUMAN
	cellular tumor antigen p53
	Phosphoprotein p53
	similar to p53 alternative splice isoform p35/HAS
	similar to transformation related protein 53
	tumor protein p53
	Tumor suppressor p53
	P-53

Organism	Rattus norvegicus
	Mus musculus
	Human

Entrez ID	24842
	22059
	7157

RGD ID	3889

Pathway	RB Tumor Suppressor
	SAPK-JNK Signaling
	Mitochondrial control of Apoptosis
	p53 Signaling
	ATM signaling
	Apoptosis
	GSK3 50
	GSK3
	AKT signaling
	DNA Repair
	PL AKT signaling
	'GSK3 50' plus

Unigene ID	Rn.54443
	Mm.222
	Hs.408312

Group	Transcription factors
	nucleotide binding
	metal ion binding

Bax

Bax Antibodies/Blocking Peptides

	Cat. No.	Product
[+]	196821	Anti-Bax (44-62) Rabbit pAb
[+]	PC66	Anti-Bax (Ab-1) (150-165) Rabbit pAb
[+]	PC66T	Anti-Bax (Ab-1) Rabbit pAb
[+]	AM13	Anti-Bax (Ab-2) Mouse mAb (ID3)
[+]	AM32	Anti-Bax (Ab-3) Mouse mAb (2D2)
[+]	PC103	Anti-Bax (Ab-4) (98-117) Rabbit pAb
[+]	AM44	Anti-Bax (Ab-6) Mouse mAb (6A7)
[+]	PP51	Bax Peptide

Bax Inhibitors

	Cat. No.	Product
[+]	196811	Bax-Inhibiting Peptide, Negative Control
[+]	196810	Bax-Inhibiting Peptide, V5

Bcl-2

Bcl-2 Antibodies/Blocking Peptides

	Cat. No.	Product
[+]	196821	Anti-Bax (44-62) Rabbit pAb
[+]	PC66	Anti-Bax (Ab-1) (150-165) Rabbit pAb
[+]	PC66T	Anti-Bax (Ab-1) Rabbit pAb
[+]	AM13	Anti-Bax (Ab-2) Mouse mAb (ID3)
[+]	AM32	Anti-Bax (Ab-3) Mouse mAb (2D2)
[+]	PC103	Anti-Bax (Ab-4) (98-117) Rabbit pAb
[+]	AM44	Anti-Bax (Ab-6) Mouse mAb (6A7)
[+]	PP51	Bax Peptide

Bcl-2 Antisense Oligonucleotides

	Cat. No.	Product
[+]	197210	bcl-2 Antisense Oligonucleotide, Control, Sodium Salt
[+]	197208	bcl-2 Antisense Oligonucleotide, Sodium Salt

Bcl-2 Assay Kit

	Cat. No.	Product
[+]	QIA23	Bcl-2 ELISA Kit

Bcl-2 Inducers/Inhibitors 

	Cat. No.	Product
[+]	197220	Bcl-2 Binding Peptide, Cell-Permeable
[+]	197225	Bcl-2 Binding Peptide, Cell-Permeable, Negative Control
[+]	197330	Bcl-2 Inhibitor
[+]	197332	Bcl-2 Inhibitor III, EM20-25
[+]	197331	Bcl-2 Inhibitor II, YC137
[+]	324768	Endostatin, Human, Recombinant, Pichia pastoris
[+]	324769	Endostatin, Mouse, Recombinant, Pichia pastoris

Bcl-2 Protein

	Cat. No.	Product
[+]	PF126	Bcl-2, C-Terminal Truncated, His•Tag®, Human, Recombinant, E. coli