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EMD Millipore
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25 May 2012
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A potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM). Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable strains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1), which initiates apoptosis. Inhibits NF-κB activation (IC50 = 3 µM). Also reported to increases the survival rate of mesenchymal stem cells following their transplantation. Prevents β-secretase cleavage. A 10 mM (1 mg/210 µl) solution of MG-132 (Cat. No. 474791) in DMSO is also available.
| Product information | |||
|---|---|---|---|
| Peptide Sequence | Z-Leu-Leu-Leu-CHO | ||
| Form | White solid | ||
| Primary Target | proteasome | ||
| Primary Target Ki | 4 nM | ||
| Secondary target | NF-κB (IC50 = 3 µM) | ||
| Molar mass | 475.6 | ||
| Cell permeable | Yes | ||
| Reversible | Yes | ||
| Purity | ≥98% by HPLC | ||
| Solubility | DMSO or EtOH | ||
| Chemical formula | C26H41N3O5 | ||
| CAS number | 133407-82-6 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
||
