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EMD Millipore
290 Concord Road
01821 Billerica, MA
United States
Phone: 781 533-6000
Fax: +49 6151 72 2000
E-mail: Customer.CareDesk@emdchemicals.com
25 May 2012
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A cell-permeable, competitive inhibitor of soluble guanylate cyclase (IC50 = 2 µM). Lowers the production of cGMP levels in a wide range of tissues by blocking intracellular Ca2+ release, with negligible effect on cAMP levels. Inhibits nitric oxide-induced smooth muscle relaxation. Shown to inhibit interleukin-1-induced cGMP accumulation in cultured rat aortic vascular smooth muscle cells. Also inhibits neutrophil chemotaxis induced by NO donors.
| Product information | |||
|---|---|---|---|
| Form | Reddish purple solid | ||
| Primary Target | soluble guanylate cyclase | ||
| Primary Target IC50 | 2 µM | ||
| Molar mass | 250.2 | ||
| Cell permeable | Yes | ||
| Purity | ≥98% by TLC and HPLC | ||
| Solubility | EtOH | ||
| Chemical formula | C15H10N2O2 | ||
| CAS number | 91300-60-6 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Harmful & Carcinogenic / Teratogenic |
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| Safety information | |||
|---|---|---|---|
| S Phrase |
S: 22-26-36/37/39-45 Do not breathe dust. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). |
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| R Phrase |
R: 22-36/37/38-45-46-48 Harmful if swallowed. Irritating to eyes, respiratory system and skin. May cause cancer. May cause heritable genetic damage. Danger of serious damage to health by prolonged exposure. |
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