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EMD Millipore
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25 May 2012
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A cell-permeable, potent, reversible and specific phosphatidylinositol 3-kinase inhibitor (IC50 = 1.4 µM) that acts on the ATP-binding site of the enzyme. Also inhibits nonhomologous DNA end-joining (NHEJ) activity of the 460 kDa phosphatidylinositol 3-like kinase DNA-PKcs, which is the catalytic subunit of DNA-activated protein kinase. Does not affect the activities of EGF receptor kinase, MAP kinase, PKC, Pl 4-kinase, S6 kinase, and c-Src even at 50 µM. Promotes the nuclear accumulation of active GSK-3b. Reported to suppress the proliferation of murine embryonic stem cells. Blocks the proliferation of cultured rabbit aortic smooth muscle cells without inducing apoptosis. A 10 mM (1 mg/325 µl) solution of LY 294002 (Cat. No. 440204) in DMSO is also available.
| Product information | |||
|---|---|---|---|
| Form | Off-white solid | ||
| Primary Target | specific phosphatidylinositol 3-kinase inhibitor | ||
| Primary Target IC50 | 1.4 µM | ||
| Molar mass | 307.4 | ||
| Protect from Light | Yes | ||
| Cell permeable | Yes | ||
| Purity | ≥98% by HPLC | ||
| Solubility | DMSO or EtOH | ||
| Chemical formula | C19H17NO3 | ||
| CAS number | 154447-36-6 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
||
