440206
LY 294002, 4′-NH2
2-(4-Morpholinyl)-8-(4-aminophenyl)-4H-1-benzopyrone-4-one, PI-828
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EMD Millipore
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25 May 2012
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A cell-permeable LY 294002 (Cat. Nos. 440202 & 440204) 4′-amino derivative with enhanced potency against p110α/β/δ/γ (IC50 in nM/-fold increase in potency = 183/2.7-, 98/5.7-, 1227/.5-, and 1967/1.9-, respectively). The molecule has been immobilized on epoxy-containing solid surface via the 4'-amine for binding studies and shown to interact with non-PI3K cellular proteins, such as mTOR, ALDH1, Brd4, GSK3β, and CKIIα.
| Product information | |||
|---|---|---|---|
| Form | Off-white solid | ||
| Molar mass | 322.4 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| Purity | ≥98% by HPLC | ||
| Solubility | DMSO | ||
| Chemical formula | C19H18N2O3 | ||
| CAS number | 942289-87-4 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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| Safety information | |||
|---|---|---|---|
| S Phrase |
S: 22-24/25-36/37/39 Do not breathe dust. Avoid contact with skin and eyes. Wear suitable protective clothing, gloves and eye/face protection. |
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