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EMD Millipore
290 Concord Road
01821 Billerica, MA
United States
Phone: 781 533-6000
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E-mail: Customer.CareDesk@emdchemicals.com
22 May 2013
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A cell-permeable, more potent inhibitor of endothelial nitric oxide synthase (eNOS; IC50 = 500 nM) compared to other arginine analogs such as L-NAME (Cat. No. 483125) and L-NMMA (Cat. No. 475886). Inhibits acetylcholine-induced relaxation of rat aorta rings (IC50 = 2 µM) and causes a dose-dependent increase in mean arterial blood pressure in the rat (EC50 = 19.5 mg/kg).
| Product information | |||
|---|---|---|---|
| Form | White solid | ||
| Primary Target | eNOS | ||
| Primary Target IC50 | 500 nM | ||
| Secondary target | acetylcholine-induced relaxation of rat aorta rings (IC50 = 2 µM) | ||
| Molar mass | 246.1 | ||
| Hygrocopic | Yes | ||
| Cell permeable | Yes | ||
| Purity | ≥98% by TLC | ||
| Solubility | H2O | ||
| Chemical formula | C7H15N3O2 · 2HCl | ||
| CAS number | 159190-44-0 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Ambient Temperature Only
Irritant |
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| Safety information | |||
|---|---|---|---|
| S Phrase |
S: 26-36 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing. |
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| R Phrase |
R: 36/37/38 Irritating to eyes, respiratory system and skin. |
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