For general questions please contact our Customer Service:
EMD Millipore
290 Concord Road
01821 Billerica, MA
United States
Phone: 781 533-6000
Fax: +49 6151 72 2000
E-mail: Customer.CareDesk@emdchemicals.com
25 May 2012
loading
A cell-permeable, reversible, and ATP-competitive inhibitor against multiple protein kinases, including, but not limited to, CaM kinase II (Ki = 1.8 nM), myosin light chain kinase (Ki = 20 nM), protein kinase A (Ki = 18 nM), protein kinase C (Ki = 25 nM), protein kinase G (Ki = 20 nM), NGF receptor gp140trk (IC50 = 3 nM), its transforming trk oncogenes, and the related neurotrophin receptors gp145trkB and gp145trkC. Reported to induce apoptosis and cell cycle arrest by decreasing Cdk1 and Cdc25c activity in T98G cells and inhibit Flt3 phosphorylation in Flt3/Itd-BaF3 cells (IC50 <50 nM). Also available as a premade 1 mM (100 µg/214 µl) solution in DMSO (Cat. No. 420297).
| Product information | |||
|---|---|---|---|
| Form | White solid | ||
| Primary Target | CaM kinase II | ||
| Primary Target Ki | 1.8 nM | ||
| Secondary target | mlck (Ki = 17 nM), PKA (Ki = 18 nM), PKC (Ki = 25 nM), and PKG (Ki = 20 nM). (IC50 = 3 nM) of the protein tyrosine kinase activity of the NGF receptor gp140trk | ||
| Molar mass | 467.5 | ||
| Protect from Light | Yes | ||
| Cell permeable | Yes | ||
| Purity | ≥95% by HPLC | ||
| Solubility | DMF or DMSO | ||
| Chemical formula | C27H21N3O5 | ||
| RTECS | NZ0550000 | ||
| CAS number | 97161-97-2 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
||
