420143
JNK3 Inhibitor XII, SR-3576
3-(4-(3-(3-Methylphenylureido))-1H-pyrazol-1-yl)-N-(3,4,5-trimethoxyphenyl)benzamide
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EMD Millipore
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25 May 2012
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A cell-permeable pyrazolourea compound that acts as a potent, ATP binding pocket-targeting, and JNK3-selective inhibitor (IC50 = 7 nM), inhibiting JNK1 only at much higher concentrations (IC50 = 170 nM) and exhibiting little activity against p38 even at concentrations as high as 20 µM. Shown to inhibit streptozotocin- (Cat. No. 572201) induced c-jun phosphorylation in INS-1 rat β-pancreatic cells (IC50 = 1.3 µM).
| Product information | |||
|---|---|---|---|
| Form | Off-white solid | ||
| Molar mass | 501.5 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| Purity | ≥95% by HPLC | ||
| Solubility | DMSO | ||
| Chemical formula | C27H27N5O5 | ||
| CAS number | 1164153-22-3 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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| Safety information | |||
|---|---|---|---|
| S Phrase |
S: 22-24/25 Do not breathe dust. Avoid contact with skin and eyes. |
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