420116
JNK Inhibitor I, (L)-Form, Cell-Permeable
(L)-JNKI1, (L)-HIV-TAT48-57-PP-JBD20, H-GRKKRRQRRRPPRPKRPTTLNLFPQVPRSQDT-NH2, c-Jun NH2-terminal kinase, SAPK Inhibitor I
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EMD Millipore
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United States
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25 May 2012
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A cell-permeable, biologically active peptide consisting of a carboxyl terminal sequence derived from the JNK-binding domain (JBD) and an amino terminal peptide containing the HIV-TAT48-57 sequence. Blocks c-Jun NH2-terminal kinase (JNK) signaling by preventing the activation of the transcription factor c-jun (IC50 ~ 1 µM). This effect appears to be due to inhibition of phosphorylation of the activation domains of JNK. Contains the minimal 20-amino acid inhibitory domain of islet-brain (IB) that is shown to be critical for interaction with JNK linked to the 10-amino acid HIV-TAT48-57 sequence as a carrier peptide and two proline residues as spacer. Inhibits IL-1β-induced c-jun and c-fos expression in insulin secreting βTC-3 cells and offers protection against apoptosis. Does not affect insulin secretion and has no effect on either ERK 1/2 or p38 activities.
| Product information | |||
|---|---|---|---|
| Peptide Sequence | H-Gly-Arg-Lys-Lys-Arg-Agr-Gln-Arg-Arg-Arg-Pro-Pro-Arg-Pro-Lys-Arg-Pro-Thr-Thr-Leu-Asn-Leu-Phe-Pro-Gln-Val-Pro-Arg-Ser-Gln-Asp-Thr-NH2 | ||
| Form | White lyophilized solid | ||
| Formulation | Supplied as a trifluoroacetate salt. | ||
| Primary Target | JNK | ||
| Primary Target IC50 | 1 µM | ||
| Molar mass | 3923.6 | ||
| Hygrocopic | Yes | ||
| Packaged under inert gas | Yes | ||
| Cell permeable | Yes | ||
| Purity | ≥97% by HPLC | ||
| Solubility | H2O | ||
| Chemical formula | C168H293N67O42 | ||
| Declaration | Sold under license of U.S. Patents 6,043,083 and 6,410,693. | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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