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EMD Millipore
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25 May 2012
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A cell-permeable hexabromocyclohexane compound that interacts with a solvent-accessible pocket near the activation loop of JAK2 and acts as a specific, reversible, and direct inhibitor of JAK2 autophosphorylation (maximal inhibition at 50 µM in BSC-40 cells overexpressing JAK2). Reduces growth hormone-mediated JAK2 activation in γ2A cells that stably express growth hormone receptor and JAK2. Does not block EGFR autophosphorylation in murine fibroblasts.
| Product information | |||
|---|---|---|---|
| Form | Off-white solid | ||
| Primary Target | JAK2 autophosphorylation | ||
| Molar mass | 557.5 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| Cell permeable | Yes | ||
| Purity | ≥ 97% by GC | ||
| Solubility | DMSO | ||
| Chemical formula | C6H6Br6 | ||
| CAS number | 1837-91-8 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
||
