688002
InSolution™ Y-27632 in DMSO
Rho Kinase Inhibitor VI, (R)-(+)-trans-N-(4-Pyridyl)-4-(1-aminoethyl)-cyclohexanecarboxamide, 2HCl
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EMD Millipore
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01821 Billerica, MA
United States
Phone: 781 533-6000
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25 May 2012
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A highly potent, cell-permeable, reversible, and selective inhibitor of Rho-associated protein kinases (Ki = 140 nM for p160ROCK). Also inhibits ROCK-II with equal potency. The inhibition is competitive with respect to ATP. Exhibits 10- to 50-fold lower affinity for PKCε than p160ROCK. Does not affect the activity of p21-activated protein kinase (PAK) even at higher concentrations (~100 µM). Also acts as a potent inhibitor of agonist-induced Ca2+ sensitization of myosin phosphorylation and smooth muscle contraction. Prevents apoptosis and enhances the survival and cloning efficiency of dissociated hES cells without affecting their pluripotency. A 5 mM (500 µg/296 µl) solution of Y-27632 (Cat. No. 688001) in H2O and the solid form of this compound (Cat. No. 688000) are also available.
| Product information | |||
|---|---|---|---|
| Form | Liquid | ||
| Formulation | A 10 mM (1 mg/296 µl) solution of Y-27632 (Cat. No. 688000)in DMSO. | ||
| Molar mass | 338.3 | ||
| Protect from Light | Yes | ||
| Hygrocopic | Yes | ||
| Avoid freeze/thaw | Yes | ||
| Purity | ≥95% by HPLC | ||
| Chemical formula | C14H21N3O•2HCl•H2O | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | ≤ -70°C | ||
| Ship |
Dry Ice Only
Irritant |
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| Safety information | |||
|---|---|---|---|
| R Phrase |
R: 36/38 Irritating to eyes and skin. |
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