444168
InSolution™ MANT-GppNHp
mant-GMPPNP, 2′/3′-O-(N-Methylanthraniloyl)-guanosine-5′-[(β,γ)-imido]triphosphate, Triethylammonium Salt, 2′/3′-O-(N-Methylanthraniloyl)-β,γ-imidoguanosine-5′-triphosphate, Triethylammonium Salt
For general questions please contact our Customer Service:
EMD Millipore
290 Concord Road
01821 Billerica, MA
United States
Phone: 781 533-6000
Fax: +49 6151 72 2000
E-mail: Customer.CareDesk@emdchemicals.com
25 May 2012
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A more lipophilic, fluorescent derivative of the GTP-hydrolysis-resistant GTP analog, GppNHp. Useful for investigating the interactions of low molecular weight GTP-binding proteins with their specific effector proteins. Acts as a potent, competitive inhibitor of adenylyl cyclase (AC; Ki = 161 nM and 155 nM in forskolin/Mn2+-stimulated AC in S49 cyc- membranes and insect cell membranes, respectively). Shown to bind to Go-proteins with high affinity, Gsα-Giα-proteins with low affinity, and ineffective at activating Gα.
| Product information | |||
|---|---|---|---|
| Form | Liquid | ||
| Formulation | A 5 mM solution in H2O. | ||
| Primary Target | AC | ||
| Primary Target Ki | 161 nM and 155 nM in forskolin/Mn2+-stimulated AC in S49 cyc- membranes and insect cell membranes, respectively | ||
| Molar mass | 958.9 | ||
| Protect from Light | Yes | ||
| Purity | ≥90% by HPLC | ||
| Excitation max. | 280 or 355 | ||
| Emission max. | 440 | ||
| Chemical formula | C18H21N7O14P3 • C18H48N3 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | ≤ -70°C | ||
| Ship |
Dry Ice Only
Standard Handling |
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