194950
InSolution™ 3′-Azido-3′-Deoxythymidine, Triphosphate, Tetralithium Salt
AZTTP
For general questions please contact our Customer Service:
EMD Millipore
290 Concord Road
01821 Billerica, MA
United States
Phone: 781 533-6000
Fax: +49 6151 72 2000
E-mail: Customer.CareDesk@emdchemicals.com
25 May 2012
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A reverse transcriptase inhibitor that acts by docking to the active site of HIV reverse transcriptase. It's inhibitory effect is greater during the initiation phase of reverse transcription. Also reported to inhibit telomerase activity in vitro (IC50 = 30 µM). Acts synergistically with Cisplatin (Cat. No. 232120) to inhibit cell proliferation in some cell lines.
Note: 1 µmol = 531 µg.
| Product information | |||
|---|---|---|---|
| Form | Liquid | ||
| Formulation | A 100 mM solution in H2O. | ||
| Primary Target | telomerase activity | ||
| Primary Target IC50 | 30 µM | ||
| Secondary target | reverse transcriptase | ||
| Molar mass | 530.9 | ||
| Protect from Light | Yes | ||
| Avoid freeze/thaw | Yes | ||
| Packaged under inert gas | Yes | ||
| Purity | ≥95% by HPLC | ||
| Chemical formula | C10H12N5O13P3 · 4Li | ||
| Store and ship information | |||
|---|---|---|---|
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Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges. |
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| Storage | ≤ -70°C | ||
| Ship |
Dry Ice Only
Toxic |
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| Safety information | |||
|---|---|---|---|
| S Phrase |
S: 36-45 Wear suitable protective clothing. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). |
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| R Phrase |
R: 23/24/25 Toxic by inhalation, in contact with skin and if swallowed. |
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