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EMD Millipore
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23 May 2013
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A cell-permeable β-carboline compound that displays anti-inflammatory properties. Acts as a potent, ATP-competitive, and reversible inhibitor of IKK (IC50 = 88 nM) with selectivity over 14 other commonly studied kinases (IC50 > 100 µM), including NF-κB inducing kinase. Blocks cellular IκBα phosphorylation and NF-κB activation (EC50 = 5 µM in TNF-α-treated HeLa cells) in vitro and reduces TNF-α release in plasma of LPS-challenged mice in vivo (50 mg/ml, p.o.).
| Product information | |||
|---|---|---|---|
| Form | Yellow solid | ||
| Molar mass | 322.8 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| Purity | ≥98% by HPLC | ||
| Solubility | DMSO | ||
| Chemical formula | C17H11ClN4O | ||
| CAS number | 431898-65-6 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
||
