401488
IKK-3 Inhibitor IX
5-(5,6-Dimethoxybenzimidazol-1-yl)-3-(2-methanesulfonyl-benzyloxy)-thiophene-2-carbonitrile
For general questions please contact our Customer Service:
EMD Millipore
290 Concord Road
01821 Billerica, MA
United States
Phone: 781 533-6000
Fax: 800-645-5439
E-mail: Customer.CareDesk@emdchemicals.com
24 May 2013
loading
A thiophenecarbonitrile compound that acts as a potent ATP-competitive inhibitor of IKK-3 (IKK-ε, IC50 = 40 nM) with ~20-fold selectivity over PLK1 and more than 125-fold selectivity over a panel of 9 other commonly studied kinases, including IKK-1/2 (IKK-α/β). Reported to be inactive against cytochrome P450 isozymes (IC50 < 50 µM) 1A2, 2D6, 2C9, and 3A4.
| Product information | |||
|---|---|---|---|
| Form | Beige solid | ||
| Molar mass | 469.5 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| Purity | ≥95% by HPLC | ||
| Solubility | DMSO | ||
| Chemical formula | C22H19N3O5S2 | ||
| CAS number | 862812-98-4 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Harmful |
||
