390602
Hydroxyfasudil
1-(1-Hydroxy-5-isoquinolinesulfonyl)homopiperazine, HCl, HA1100
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EMD Millipore
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25 May 2012
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A cell-permeable, hydroxylated metabolite of HA 1077 (Fasudil; Cat. No. 371970) that displays anti-anginal properties. Acts as an ATP-competitive and a reversible inhibitor of Rho-kinase (IC50 = 0.9 and 1.8 µM using a peptide and MLC as substrate, respectively) with ~100-fold greater selectivity over MLCK, MRCKβ, and PKC. Reported to inhibit the Rho kinase-mediated contraction both in vitro and in vivo.
| Product information | |||
|---|---|---|---|
| Form | Liquid | ||
| Formulation | A 10 mM (2 mg/582 µl) solution in H2O. | ||
| Primary Target | Rho-kinase | ||
| Primary Target IC50 | 0.9 and 1.8 µM using a peptide and MLC as substrate, respectively | ||
| Molar mass | 343.8 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| Cell permeable | Yes | ||
| ATP Competitive | Yes | ||
| Purity | ≥98% by HPLC | ||
| Chemical formula | C14H17N3O3S • HCl | ||
| CAS number | 155558-32-0 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Blue Ice Only
Harmful |
||
