382148
Histone Deacetylase Inhibitor II
CBHA, m-Carboxycinnamic Acid bis-Hydroxamide
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EMD Millipore
290 Concord Road
01821 Billerica, MA
United States
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25 May 2012
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A cell-permeable second generation hybrid polar agent that acts as a histone deacetylase (HDAC) inhibitor. The HDAC inhibition is believed to arise as a result of the binding of the hydroxamic moiety to the active site zinc. Shown to be a potent inducer of transformed cell growth arrest and terminal differentiation (~4 µM). Induces apoptosis and the CD95/CD95-Ligand expression in human neuroblastoma.
| Product information | |||
|---|---|---|---|
| Form | Off-white solid | ||
| Primary Target | HDAC | ||
| Molar mass | 222.2 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| Cell permeable | Yes | ||
| Purity | ≥95% by HPLC | ||
| Solubility | DMSO | ||
| Chemical formula | C10H10N2O4 | ||
| CAS number | 174664-65-4 | ||
| Declaration | Not available for sale in the United States. | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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