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EMD Millipore
290 Concord Road
01821 Billerica, MA
United States
Phone: 781 533-6000
Fax: 800-645-5439
E-mail: Customer.CareDesk@emdchemicals.com
24 May 2013
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A cell-permeable, reversible, and ATP-competitive Ca2+ antagonist with anti-vasospastic properties. Inhibits protein kinase A (Ki = 1.6 µM), protein kinase G (Ki = 1.6 µM), and myosin light chain kinase (Ki = 36 µM). Also reported to potently inhibit Rho-associated kinase (ROCK; IC50 = 10.7 µM). Prevents apoptosis and enhances the survival and cloning efficiency of dissociated hES cells without affecting their pluripotency.
| Product information | |||
|---|---|---|---|
| Form | White solid | ||
| Primary Target | PKA | ||
| Primary Target IC50 | 1.6 µM | ||
| Secondary target | protein kinase G (IC50 = 1.6 µM), myosin light chain kinase (IC50 = 36 µM), ROCK (IC50 = 10.7 µM) | ||
| Molar mass | 364.3 | ||
| Cell permeable | Yes | ||
| Purity | ≥98% by HPLC | ||
| Solubility | H2O | ||
| Chemical formula | C14H17N3O2S · 2HCl | ||
| CAS number | 103745-39-7 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Harmful |
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| Safety information | |||
|---|---|---|---|
| S Phrase |
S: 36 Wear suitable protective clothing. |
||
| R Phrase |
R: 20/21/22 Harmful by inhalation, in contact with skin and if swallowed. |
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