361540
GSK-3β Inhibitor I
TDZD-8, 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione
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EMD Millipore
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25 May 2012
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A thiadiazolidinone (TDZD) analog that acts as a highly selective, non-ATP competitive inhibitor of GSK-3β (IC50 = 2 µM). Inhibits Flt-3 and PKC activities (IC50 = 673 nM and 1.4-5.5 µM, respectively). Does not significantly affect the activities of Cdk-1/cyclin B, CK-II, and PKA, (IC50 > 100 µM). Binds to the active site of GSK-3β.
| Product information | |||
|---|---|---|---|
| Form | White to off-white solid | ||
| Primary Target | Gsk-3β | ||
| Primary Target IC50 | 2 µM | ||
| Secondary target | Cdk-1/cyclin B, CK-II, PKA, and PKC (IC50 > 100 µM) | ||
| Molar mass | 222.3 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| Purity | ≥ 95% by HPLC | ||
| Solubility | DMSO | ||
| Chemical formula | C10H10N2SO2 | ||
| CAS number | 327036-89-5 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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