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25 May 2012
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A cell-permeable bis-indolo (indirubin) compound that acts as a highly potent, selective, reversible, and ATP-competitive inhibitor of GSK-3α/β (IC50 = 5 nM). Its specificity has been tested against various Cdk's (IC50 = 83, 300, 320, and 10,000 nM for Cdk5/p25, Cdk2/A, Cdk1/B, and Cdk4/D1, respectively) as well as many other commonly studied kinases (IC50 ≥ 10 µM), including MAP kinases, PKA, PKC isoforms, PKG, CK, and IRTK. Inhibition of GSK by BIO has been shown to result in the activation of Wnt-signaling pathway and sustained pluripotency in human and murine ESCs (embryonic stem cells). Reported to maintain self-renewal in human and mouse embryonic stem cells. Also induces the differentiation of neonatal cardiomyocytes. A 10 mM (500 µg/140 µl) solution of GSK-3 Inhibitor IX (Cat. No. 361552) in DMSO is also available.
| Alternatives | |
|---|---|
| 361552 | InSolution™ GSK-3 Inhibitor IX |
| 361556 | GSK-3 Inhibitor IX, Control, MeBIO |
| Alternative products for GSK-3 Inhibitor IX | |
| 361552 | InSolution™ GSK-3 Inhibitor IX |
| 361556 | GSK-3 Inhibitor IX, Control, MeBIO |
| Accessories for GSK-3 Inhibitor IX |
| Product information | |||
|---|---|---|---|
| Form | Purple solid | ||
| Primary Target | GSK-3α/β | ||
| Primary Target IC50 | 5 nM | ||
| Secondary target | IC50 = 83, 300, 320, and 10,000 nM for Cdk5/p25, Cdk2/A, Cdk1/B, and Cdk4/D1, respectively | ||
| Molar mass | 356.2 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| Cell permeable | Yes | ||
| Purity | ≥97% by HPLC | ||
| Solubility | DMSO | ||
| Chemical formula | C16H10BrN3O2 | ||
| CAS number | 667463-62-9 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Shipped with Blue Ice or with Dry Ice
Carcinogenic / Teratogenic |
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| Safety information | |||
|---|---|---|---|
| S Phrase |
S: 22-36/37 Do not breathe dust. Wear suitable protective clothing and gloves. |
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| R Phrase |
R: 20/21/22 Harmful by inhalation, in contact with skin and if swallowed. |
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