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EMD Millipore
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25 May 2012
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A cell-permeable N-methylated analog of GSK-3 Inhibitor IX, BIO (Cat. No. 361550) that serves as a relevant kinase inactive control (IC50 > 92 µM for Cdk1/B, > 100 µM for Cdk5/p25, and GSK-3α/β). Acts as a potent ligand for aryl hydrocarbon receptor (AhR; EC50 = 20 nM and 93 nM for yeast and hepatoma reporter systems, respectively) and displays antiproliferative properties.
| Alternatives | |
|---|---|
| 361550 | GSK-3 Inhibitor IX |
| 361552 | InSolution™ GSK-3 Inhibitor IX |
| Alternative products for GSK-3 Inhibitor IX, Control, MeBIO | |
| 361550 | GSK-3 Inhibitor IX |
| 361552 | InSolution™ GSK-3 Inhibitor IX |
| Accessories for GSK-3 Inhibitor IX, Control, MeBIO |
| Product information | |||
|---|---|---|---|
| Form | Dark red solid | ||
| Primary Target | GSK-3α/β | ||
| Primary Target IC50 | 5 nM | ||
| Secondary target | IC50 >92 µM for Cdk1/B, >100 µM for Cdk5/p25, and GSK-3α/β | ||
| Molar mass | 370.2 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| Cell permeable | Yes | ||
| ATP Competitive | Yes | ||
| Purity | ≥97% by HPLC | ||
| Solubility | DMSO | ||
| Chemical formula | C17H12BrN3O2 | ||
| CAS number | 710323-61-8 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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