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371715  Gliotoxin, Gladiocladium fimbriatum - CAS 67-99-2 - Calbiochem

2,3,5a,6-Tetrahydro-6-hydroxy-3(hyroxymethyl)-2-methyl-10H-3a,10a-epidithio-pyrazinol[1,2α]indole-1,4-dione

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23 April 2014

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371715-1MG  1 mg 
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An immunosuppressive secondary metabolite produced by several pathogenic fungi. Immunosuppressive effects are caused by blocking of membrane thiol groups. Causes apoptotic cell death in a variety of cell types including macrophages and thymocytes. Farnesyltransferase (FTase) inhibitor (IC50 = 1.1 µM). Reported to increase ryanodine Ca2+ channel activity possibly by oxidizing cysteine residues located on the ryanodine receptor. Specifically inhibits NF-κB activation in B and T cells at nanomolar concentrations.
Product information
Form White solid
Primary Target FTase
Primary Target IC50 1.1 µM
Molar mass 326.4
Purity ≥98% by TLC
Solubility DMSO or EtOH
Chemical formula C13H14N2O4S2
RTECS KB4725000
CAS number 67-99-2
Merck USA index 14, 4441
Store and ship information

Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Storage +2°C to +8°C
Ship Ambient Temperature Only
Toxic
Safety information
S Phrase S: 36/37/39-45

Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
R Phrase R: 23/24/25

Toxic by inhalation, in contact with skin and if swallowed.
Gliotoxin, <i>Gladiocladium fimbriatum</i> - CAS 67-99-2 - Calbiochem, molecular structure

© Merck KGaA, Darmstadt, Germany, 2014

All references to Merck refer to Merck KGaA, Darmstadt, Germany.


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