345885
GGTI-2147
4-[[N-(Imidazol-4-yl)methyleneamino]-2-(1-naphthyl)benzoyl]leucine methyl ester
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EMD Millipore
290 Concord Road
01821 Billerica, MA
United States
Phone: 800-645-5476
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E-mail: Customer.CareDesk@emdchemicals.com
19 June 2013
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A cell-permeable non-thiol peptidomimetic that acts as a potent and selective inhibitor of geranylgeranyltransferase I (GGTase I). Blocks the geranyl-geranylation of Rap1A with an IC50 value that is over 60-fold lower than that required to disrupt the farnesylation of H-Ras (IC50 = 500 nM for Rap1A versus IC50 > 30 µM for H-Ras).
| Product information | |||
|---|---|---|---|
| Form | Off-white solid | ||
| Primary Target | GGTase-I | ||
| Secondary target | Rap 1A (IC50 = 500 nM) | ||
| Molar mass | 470.6 | ||
| Hygrocopic | Yes | ||
| Packaged under inert gas | Yes | ||
| Cell permeable | Yes | ||
| Purity | ≥95% by HPLC | ||
| Solubility | DMSO | ||
| Chemical formula | C28H30N4O3 | ||
| CAS number | 191102-87-1 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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