344510
FTase Inhibitor I
N-[2(S)-[2(R)-Amino-3-mercaptopropylamino]-3-methylbutyl]-Phe-Met-OH, B581
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EMD Millipore
290 Concord Road
01821 Billerica, MA
United States
Phone: 781 533-6000
Fax: +49 6151 72 2000
E-mail: Customer.CareDesk@emdchemicals.com
25 May 2012
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A potent, cell-permeable, selective, peptidomimetic inhibitor of farnesyltransferase (FTase) that is approximately 37-fold more active against FTase (IC50 = 21 nM in vitro) than against geranylgeranyltransferase (GGTase; IC50 = 790 nM). Very resistant to proteolysis.
| Product information | |||
|---|---|---|---|
| Form | White solid | ||
| Formulation | Supplied as a trifluoroacetate salt. | ||
| Primary Target | FTase | ||
| Primary Target IC50 | 21 nM in vitro | ||
| Secondary target | GGTase (IC50 = 790 nM) | ||
| Molar mass | 470.7 | ||
| Hygrocopic | Yes | ||
| Packaged under inert gas | Yes | ||
| Cell permeable | Yes | ||
| Purity | ≥90% by HPLC | ||
| Solubility | DMSO or H2O | ||
| Chemical formula | C22H38N4O3S2 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
||
