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EMD Millipore
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01821 Billerica, MA
United States
Phone: 781 533-6000
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25 May 2012
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A peptide corresponding to amino acid residues 188 - 226 of FRAT1 (frequently rearranged in advanced T-cell lymphomas 1), a mammalian homolog of GSK-3 binding protein. Binds to the carboxyl-terminal lobe of GSK-3 (glycogen synthase kinase-3) and prevents the binding of “unprimed” substrates such as axin, β-catenin and tau. Exhibits little effect on GSK-3 catalyzed phosphorylation of “primed” (pre-phosphorylated) substrates such as glycogen synthase and eIF2B (elongation initiation factor 2B).
| Product information | |||
|---|---|---|---|
| Peptide Sequence |
H-Ser-Gln-Pro-Glu-Thr-Arg-Thr-Gly-Asp-Asp-Asp-Pro-His-Arg-Leu-Leu-Gln-Gln-Leu-Val- Leu-Ser-Gly-Asn-Leu-Ile-Lys-Glu-Ala-Val-Arg-Arg-Leu-His-Ser-Arg-Arg-Leu-Gln-OH |
||
| Form | White solid | ||
| Formulation | Supplied as a trifluoroacetate salt. | ||
| Molar mass | 4534.1 | ||
| Hygrocopic | Yes | ||
| Packaged under inert gas | Yes | ||
| Purity | ≥95% by HPLC | ||
| Solubility | DMSO or H2O | ||
| Chemical formula | C192H327N67O60 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Blue Ice Only
Standard Handling |
||
