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EMD Millipore
290 Concord Road
01821 Billerica, MA
United States
Phone: 781 533-6000
Fax: +49 6151 72 2000
E-mail: Customer.CareDesk@emdchemicals.com
25 May 2012
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Kindly contact Customer Service to order this product.
This product has been discontinued.
Please refer to our complete listing of NF-κB activation inhibitors for possible alternatives. Please read the alternative product documentation carefully and contact technical service if you need additional information.
A cell-permeable quinazolinocarboline alkaloid that displays antiproliferative, antimetastatic, apoptotic, vasorelaxant and vanilloid receptor agonist activities. Suppresses both inducible (≤ 250 nM in KBM-5, H1299, A293 and Jurkat T cells stimulated with 0.1 nM of TNF) and constitutive (> 500 nM in FaDU and U266 cells) NF-κB activation and NF-κB-regulated gene expression by inhibiting IκBα kinase (IKK) activation. Further, shown to selectively abrogate TNF-induced Akt activation and its association with IKK with no effects on JNK and p38MAPK activation, and promote the phosphorylations of Raf-1 kinase and Bcl-2.
| Product information | |||
|---|---|---|---|
| Form | Light yellow solid | ||
| Primary Target | inducible NF-κB | ||
| Primary Target IC50 | <250 nM | ||
| Secondary target | consituted NF-κB (IC50 > 500 nM) | ||
| Molar mass | 303.4 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| Cell permeable | Yes | ||
| Purity | ≥95% by HPLC | ||
| Solubility | DMSO | ||
| Chemical formula | C19H17N3O | ||
| CAS number | 518-17-2 | ||
| Merck USA index | 14, 3908 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Shipped with Blue Ice or with Dry Ice
Standard Handling |
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