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25 May 2012
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Principal alkaloid of ipecac, isolated from the ground roots of Uragoga ipecacuanha. Irreversibly blocks protein synthesis in eukaryotes by inhibiting the movement of ribosomes along the mRNA. Induces hypotension by blocking adrenoreceptors. Interferes with cytometric analysis of DNA replication at the early S phase. Also identified as a specific inhibitor of HIF-2α protein stability and transcriptional activity (IC50 ≤1 µM.
| Product information | |||
|---|---|---|---|
| Form | White solid with a faint yellow cast | ||
| Primary Target | movement of ribosomes along the mRNA | ||
| Molar mass | 553.6 | ||
| Protect from Light | Yes | ||
| Hygrocopic | Yes | ||
| Purity | ≥98% by HPLC and Titration (dried basis) (perchloric acid method) | ||
| Solubility | EtOH or H2O | ||
| Chemical formula | C29H40N2O4 · 2HCl | ||
| RTECS | JY5250000 | ||
| CAS number | 316-42-7 | ||
| Merck USA index | 14, 3559 | ||
| Store and ship information | |||
|---|---|---|---|
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Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges. |
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| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Highly Toxic |
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| Safety information | |||
|---|---|---|---|
| S Phrase |
S: 28-36/37-45 Wear suitable protective clothing and gloves. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). |
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| R Phrase |
R: 28-36/38 Very toxic if swallowed. Irritating to eyes and skin. |
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