287897
Dicoumarol
3,3′-Methylenebis(4-hydroxycoumarin), Bishydroxycoumarin, Dicumarol
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EMD Millipore
290 Concord Road
01821 Billerica, MA
United States
Phone: 781 533-6000
Fax: +49 6151 72 2000
E-mail: Customer.CareDesk@emdchemicals.com
25 May 2012
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A cell-permeable quinone reductase inhibitor with anticoagulant properties. Potentiates apoptosis by simultaneously blocking SAPK/JNK and NF-κB pathways. Does not affect phosphorylation of p38 or activation of AKT. Blocks brefeldin A-dependent mono-ADP-ribosylation in vitro and Golgi disassembly in living cells (IC50 = 180 µM and 150 µM, respectively).
| Product information | |||
|---|---|---|---|
| Form | White solid | ||
| Primary Target | Blocks brefeldin A-dependent mono-ADP-ribosylation in vitro | ||
| Primary Target IC50 | 180 µM | ||
| Secondary target | Golgi disassembly in living cells IC50 = 150 µM | ||
| Molar mass | 336.3 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| Purity | ≥98% by titration | ||
| Solubility | Aqueous alkaline solutions or organic bases | ||
| Chemical formula | C19H12O6 | ||
| RTECS | GN7875000 | ||
| CAS number | 66-76-2 | ||
| Merck USA index | 14, 3090 | ||
| Store and ship information | |||
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Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges. |
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| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Toxic & Carcinogenic / Teratogenic |
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| Safety information | |||
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| S Phrase |
S: 37-45-61 Wear suitable gloves. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). Avoid release to the environment. Refer to special instructions/safety data sheet. |
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| R Phrase |
R: 22-48/25-51/53 Harmful if swallowed. Toxic: danger of serious damage to health by prolonged exposure if swallowed. Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. |
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