For general questions please contact our Customer Service:
EMD Millipore
290 Concord Road
01821 Billerica, MA
United States
Phone: 781 533-6000
Fax: +49 6151 72 2000
E-mail: Customer.CareDesk@emdchemicals.com
25 May 2012
loading
An acid-labile resin for the preparation of N-acyl or N-alkyl cysteamines. The free amino functionality of the resin-bound cysteamine can be readily acylated or reductively alkylated using standard procedures. Cleavage can be effected with electrophilic oxidants such as I2 or Tl3+ to produce a dimeric disulfide bridged product, or with 50-100% TFA to give the monomeric sulfhydryl product. Peptidylaminoethylthiols produced in this manner have been used to prepare PEG-conjugates by chemoselective ligation to pegylated maleimide [1]. This method is particularly useful for forming intramolecular disulfide bridges in molecules containing two thiol groups where one is protected with Acm.
For a similar application, see [2, 3, 4].
The product number for this product was previously 01-64-0107.
To obtain a certificate of analysis (CoA) of a lot that begins with the letter "A", please click here; otherwise please use the option in the "About this product" menu.
For a similar application, see [2, 3, 4].
The product number for this product was previously 01-64-0107.
To obtain a certificate of analysis (CoA) of a lot that begins with the letter "A", please click here; otherwise please use the option in the "About this product" menu.
| Store and ship information | |||
|---|---|---|---|
| Storage | +2 to +8°C | ||
