233183
Clodronate, Disodium Salt
Clodronate, Disodium, Tetrahydrate, Dichloromethylene-bisphosphonate, Disodium Tetrahydrate
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EMD Millipore
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25 May 2012
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A non-amino, chloro-containing bisphosphonate that acts as a potent inhibitor of osteoclast-mediated bone resorption. It is metabolized into a non-hydrolyzable ATP analog in osteoclasts and macrophages, and induces apoptosis by inhibiting mitochondrial function. An efficient metal chelator that inhibits invasion, adhesion, and migration of PC-3 prostate cancer cells (IC50 = 100 nM).
| Product information | |||
|---|---|---|---|
| Form | White solid | ||
| Molar mass | 360.9 | ||
| Hygrocopic | Yes | ||
| Purity | ≥97% by titration | ||
| Solubility | H2O | ||
| Chemical formula | CH2Cl2O6P2Na2 • 4H2O | ||
| RTECS | SZ7640700 | ||
| CAS number | 22560-50-5 | ||
| Merck USA index | 14, 2371 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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