480741
Cleaved Cdk5 Activator, p35, GST-Fusion, Bovine, Recombinant, E. coli
Nck5a, Neuronal Cdk5 Activator, p25nck5a/p35nck5a
For general questions please contact our Customer Service:
EMD Millipore
290 Concord Road
01821 Billerica, MA
United States
Phone: 781 533-6000
Fax: +49 6151 72 2000
E-mail: Customer.CareDesk@emdchemicals.com
25 May 2012
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Recombinant, bovine cleaved Cdk5 activator (p35) fused to GST and expressed in E. coli. It is produced as a 35 kDa precursor and further cleaved into the 25 kDa form of the protein. Cleaved Cdk5 activator is an essential regulating subunit of cdk5. Aberrant Cdk5 activity has been implicated in a number of neurodegenerative diseases such as Alzheimer's disease, amyotrophic lateral sclerosis, and Parkinson's disease, where abnormal phosphorylation of tau and/or neurofilaments has been observed. One vial contains sufficient material for approximately 25 reactions.
| Product information | |||
|---|---|---|---|
| Form | Liquid | ||
| Formulation | In 25 mM Tris-HCl, 100 µM DTT, 30% glycerol, pH 7.4. | ||
| Molar mass | 51000 | ||
| Avoid freeze/thaw | Yes | ||
| Specific activity | ≥100,000 units/mg protein | ||
| Unit definition | One unit is defined as the amount of protein that when reconstituted with Cdk5 (Cat. No. 219459) will transfer 1 pmol of phosphate to Histone H1 peptide (9-18) per min at 30°C, pH 7.2. | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Blue Ice Only
Standard Handling |
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