220557
Chlorhexidine, Dihydrochloride
1,6-bis[N′-(p-Chlorophenyl)-N5-biguanido]hexane, 2HCl, CHX
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EMD Millipore
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01821 Billerica, MA
United States
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25 May 2012
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An anti-microbial agent that acts as an inhibitor of MMP-2 and MMP-9; however, MMP-2 is more sensitive to chlorhexidine than MMP-9. Inhibits the collagenase activity of MMP-8 released by PMA-triggered polymorphonuclear leukocytes (PMNs) in a dose-dependent manner. CHX may possibly act through a cation-chelating mechanism.
Note: presence of CaCl2 in the medium blocks the inhibitory activity of CHX.
| Product information | |||
|---|---|---|---|
| Form | White solid | ||
| Primary Target | MMP-2, MMP-9 | ||
| Secondary target | MMP-8 collagenase activity | ||
| Molar mass | 578.4 | ||
| Hygrocopic | Yes | ||
| Packaged under inert gas | Yes | ||
| Purity | ≥95% by titration | ||
| Solubility | DMSO | ||
| Chemical formula | C22H30Cl2N10 · 2HCl | ||
| RTECS | XA5285000 | ||
| CAS number | 3697-42-5 | ||
| Merck USA index | 14, 2091 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Irritant |
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| Safety information | |||
|---|---|---|---|
| S Phrase |
S: 26-36 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing. |
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| R Phrase |
R: 36/37/38 Irritating to eyes, respiratory system and skin. |
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