220486
Chk2 Inhibitor II
2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide, Checkpoint Kinase Inhibitor IV
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EMD Millipore
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24 May 2013
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A cell-permeable and reversible benzimidazolo compound that acts as a potent and ATP-competitive inhibitor of Chk2 with an IC50 of 15 nM and a Ki of 37 nM. Displays ~ 1,000-fold greater selectivity over Cdk1/B and CK1 (IC50 = 12 µM and 17 µM, respectively) and only weakly affects the activities of a panel of 31 kinases (< 25% inhibition at 10 µM), including Chk1. Shown to rescue both peripheral CD4+ and CD8+ T-cells from γ-irradiation-induced apoptosis with an EC50 of 3 µM and 7.6 µM, respectively. Also available as a 25 mM solution in DMSO (Cat. No. 220491).
| Alternatives | |
|---|---|
| CBA020 | K-LISA™ Checkpoint Activity Kit |
| Alternative products for Chk2 Inhibitor II | |
| CBA020 | K-LISA™ Checkpoint Activity Kit |
| Accessories for Chk2 Inhibitor II |
| Product information | |||
|---|---|---|---|
| Form | Pale yellow solid | ||
| Primary Target | Chk2 | ||
| Primary Target IC50 | 15 nM | ||
| Primary Target Ki | 37 nM | ||
| Secondary target | Cdk1/B and CK1 (IC50 = 12 µM and 17 µM, respectively) | ||
| Molar mass | 363.8 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| Cell permeable | Yes | ||
| ATP Competitive | Yes | ||
| Purity | ≥95% by HPLC | ||
| Solubility | DMSO | ||
| Chemical formula | C20H14ClN3O2 | ||
| CAS number | 516480-79-8 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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