220005
CGP-37157
7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one
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25 May 2012
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A cell-permeable benzothiazepine derivative of clonazepam that acts as a specific and potent inhibitor of the mitochondrial Na+/Ca2+ exchanger (IC50 = 360 nM). Enhances the export of Ca2+ from isolated mitochondria. Also reported to directly inhibit voltage-gated Ca2+ channels.
| Product information | |||
|---|---|---|---|
| Form | White solid | ||
| Primary Target | mitochondrial Na+/Ca2+ exchanger | ||
| Primary Target IC50 | 360 nM | ||
| Molar mass | 324.2 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| Cell permeable | Yes | ||
| Purity | ≥98% by TLC | ||
| Solubility | DMSO | ||
| Chemical formula | C15H11Cl2NOS | ||
| CAS number | 75450-34-9 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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