238804
Cdk2 Inhibitor IV, NU6140
4-(6-Cyclohexylmethoxy-9H-purin-2-ylamino)-N,N-diethylbenzamide
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EMD Millipore
290 Concord Road
01821 Billerica, MA
United States
Phone: 781 533-6000
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E-mail: Customer.CareDesk@emdchemicals.com
25 May 2012
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A highly cell-permeable purine compound that displays anticancer properties and acts as a selective and ATP-competitive inhibitor of Cdks (IC50 = 6.6 µM, 0.41 µM, 5.5 µM, 15 µM and 3.9 µM for Cdk1/cyclin B, Cdk2/cyclin A, Cdk4/cyclin D, Cdk5/p25 and Cdk7/cyclin H, respectively). Shown to cause cell cycle arrest at the G2/M phase and induce apoptosis by activating caspases and down-regulation survivin. Synergistically potentiates paclitaxel cytotoxicity and apoptotic response in HeLa and OAW42 cells.
| Product information | |||
|---|---|---|---|
| Form | Off-white solid | ||
| Primary Target | Cdk1/cyclin B | ||
| Primary Target IC50 | 6.6 µM | ||
| Secondary target | IC50 = 0.41 µM, 5.5 µM, 15 µM and 3.9 µM for Cdk2/cyclin A, Cdk4/cyclin D, Cdk5/p25 and Cdk7/cyclin H, respectively | ||
| Molar mass | 422.5 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| Cell permeable | Yes | ||
| ATP Competitive | Yes | ||
| Purity | ≥95% by HPLC | ||
| Solubility | DMSO | ||
| Chemical formula | C23H30N6O2 | ||
| CAS number | 444723-13-1 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Carcinogenic / Teratogenic |
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