238806
Cdk2/9 Inhibitor
(4-(2-Amino-4-methylthiazol-5-yl)pyrimidin-2-yl)-(3-nitrophenyl)amine
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EMD Millipore
290 Concord Road
01821 Billerica, MA
United States
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E-mail: Customer.CareDesk@emdchemicals.com
21 May 2013
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A cell-permeable aminopyrimidinyl compound that acts as a potent and ATP-competitive inhibitor of Cdk2/E and Cdk9/T1 (Ki = 2 nM and 4 nM, respectively). It also inhibits GSK-3β, Cdk4/D1, Cdk7/H, Cdk1/B, and Abl at higher concentrations (Ki = 20, 53, 70, 80, and 160 nM, respectively), but exhibits little activity towards 9 other kinases (Ki > 1.0 µM). Shown to inhibit phosphorylation of cellular Cdk substrates, pRb and RNA polymerase II, and Cdk2-mediated S-phase transition.
| Product information | |||
|---|---|---|---|
| Form | Yellow solid | ||
| Molar mass | 328.4 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| Purity | ≥95% by HPLC | ||
| Solubility | DMSO | ||
| Chemical formula | C14H12N6O2S | ||
| CAS number | 507487-89-0 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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