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EMD Millipore
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26 May 2013
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An aminopyrimidine derivative that acts as a selective and ATP-competitive inhibitor of Cdk2/cyclin E and Cdk5/p25 (Ki = 2 µM). Binds to the ATP-binding pocket of Cdk2. Does not affect the activities of c-Met, IGF-1 receptor tyrosine kinase, cAMP-dependent kinase, and ERK2 at concentrations as high as 100 µM.
| Product information | |||
|---|---|---|---|
| Form | White solid | ||
| Primary Target | CDK2 | ||
| Primary Target Ki | 2 µM | ||
| Secondary target | ERK2 at concentrations as high as 100 µM | ||
| Molar mass | 301.8 | ||
| Protect from Light | Yes | ||
| Hygrocopic | Yes | ||
| Packaged under inert gas | Yes | ||
| ATP Competitive | Yes | ||
| Purity | ≥95% by HPLC | ||
| Solubility | DMSO | ||
| Chemical formula | C10H11N5O2S · HCl | ||
| CAS number | 21886-12-4 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
||
