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EMD Millipore
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25 May 2012
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A 3-amino substituted pyrazoloquinoxaline compound that acts as a selective inhibitor of cyclin-dependent kinases 1 and 5 (Cdks; IC50 = 0.6 µM and 0.4 µM for Cdk1/cyclin B and Cdk5/p25, respectively). Also shown to inhibit GSK-3β with (IC50 = 1 µM). Does not inhibit Cdc25 phosphatase activity (IC50 > 10 µM).
| Product information | |||
|---|---|---|---|
| Form | Red solid | ||
| Primary Target | Cdk1/cyclin B, Cdk5/p25 | ||
| Primary Target IC50 | 0.6 µM, 0.4 µM | ||
| Secondary target | GSK-3β (IC50 = 1 µM) | ||
| Molar mass | 185.2 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| Purity | ≥95% by HPLC | ||
| Solubility | DMSO | ||
| Chemical formula | C9H7N5 | ||
| CAS number | 40254-90-8 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
||
