217714
Cdk1/2 Inhibitor III
5-Amino-3-((4-(aminosulfonyl)phenyl)amino)-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide
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EMD Millipore
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United States
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19 May 2013
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A cell-permeable triazolo-diamine compound that displays anti-proliferative properties in various human cancer cells (IC50 = 20 nM, 35 nM and 92 nM in HCT-116, HeLa, and A375 cells, respectively). Acts as a highly potent, reversible, ATP-competitive inhibitor of Cdk1/cyclin B and Cdk2/cyclin A (IC50 = 600 pM and 500 pM, respectively) with selectivity over VEGF-R2 (IC50 = 32 nM), GSK-3β (IC50 = 140 nM), and a panel of eight other kinases (IC50 ≥ 1 µM).
| Product information | |||
|---|---|---|---|
| Form | White solid | ||
| Primary Target | Cdk1/cyclin B, Cdk2/cyclin A | ||
| Primary Target IC50 | 600 pM, 500 pM | ||
| Secondary target | VEGF-R2 (IC50 = 32 nM), GSK-3η(IC50 = 140 nM) | ||
| Molar mass | 425.4 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| Cell permeable | Yes | ||
| ATP Competitive | Yes | ||
| Purity | ≥95% by HPLC | ||
| Solubility | DMSO | ||
| Chemical formula | C15H13F2N7O2S2 | ||
| CAS number | 443798-55-8 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Harmful |
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