219479
Cdc2-Like Kinase Inhibitor, TG003
(Z)-1-(3-Ethyl-5-methoxy-2,3-dihydrobenzothiazol-2-ylidene)propan-2-one, Clk Inhibitor, TG003
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25 May 2012
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A cell-permeable dihydrobenzothiazolo compound that acts as a potent, specific, reversible, and ATP-competitive inhibitor of Clk-family of kinases (Ki = 10 nM for mClk1/Sty; IC50 = 15 nM, 20 nM, 200 nM, and > 10 µM for mClk4, mClk1, mClk2, and mClk3, respectively). Does not affect the activities of SRPK1, SRPK2, PKA, or PKC up to 1 µM. Shown to alter the regulation of alternative splicing mediated by phosphorylation of Ser/Arg-rich (SR) proteins both in vitro and in vivo. Suppresses early Xenopus developmental abnormality induced by excess levels of Clk-activity.
| Product information | |||
|---|---|---|---|
| Form | Off-white solid | ||
| Primary Target | mClk4, mClk1, mClk2, mClk3 | ||
| Primary Target IC50 | 15 nM, 20 nM, 200 nM, >10 µM | ||
| Molar mass | 249.3 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| Cell permeable | Yes | ||
| Reversible | Yes | ||
| ATP Competitive | Yes | ||
| Purity | ≥98% by HPLC | ||
| Solubility | DMSO or MeOH | ||
| Chemical formula | C13H15NO2S | ||
| CAS number | 300801-52-9 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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