For general questions please contact our Customer Service:
EMD Millipore
290 Concord Road
01821 Billerica, MA
United States
Phone: 781 533-6000
Fax: +49 6151 72 2000
E-mail: Customer.CareDesk@emdchemicals.com
25 May 2012
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This product has been discontinued.
Please refer to our complete listing of caspase inhibitors for possible alternatives. Please read the alternative product documentation carefully and contact technical service if you need additional information.
A benzodioxane containing 2,4-disubstituted thiazolo compound that acts as a selective, reversible and competitive inhibitor of caspases (Ki = 4.3 µM, 6.2 µM and 2.7 µM for caspase-3, -7 and -8, respectively). The benzodioxane moiety is shown to fit in the 'aspartate hole' of the caspases and possibly disrupt caspase-8 assisted cleavage of BID, a proapoptotic protein. Weakly affects the activity of anthrax lethal factor, a metalloprotease, at ~20 µM.
| Product information | |||
|---|---|---|---|
| Peptide Sequence | Bl-9B12 | ||
| Form | White solid | ||
| Primary Target | caspase-3 | ||
| Primary Target Ki | 4.3 µM | ||
| Secondary target | (Ki = 6.2 µM and 2.7 µM for caspase -7 and -8, respectively) | ||
| Molar mass | 363.4 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| Reversible | Yes | ||
| Purity | ≥97% by HPLC | ||
| Solubility | DMSO or MeOH | ||
| Chemical formula | C18H12F3NO2S | ||
| CAS number | 848782-29-6 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Standard Handling |
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