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400012  Caspase-1 Inhibitor II

IL-1β Converting Enzyme (ICE) Inhibitor II, Ac-YVAD-CMK

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21 May 2013

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400012-5MG  5 mg 
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A cell-permeable and irreversible inhibitor of caspase-1 (Ki = 760 pM), caspase-4, and caspase-5. Inhibits Fas-mediated apoptosis and acidic sphingomyelinase activation.
Product information
Peptide Sequence Ac-Tyr-Val-Ala-Asp-CMK
Form White solid
Primary Target caspase-1
Primary Target Ki 760 pM
Secondary target caspase-4, caspase-5
Molar mass 541.0
Protect from Moisture Yes
Cell permeable Yes
Purity ≥95% by HPLC
Solubility DMSO
Chemical formula C24H33ClN4O8
CAS number 178603-78-6
Store and ship information
Storage -20°C
Ship Ambient Temperature Only
Standard Handling
Caspase-1 Inhibitor II, molecular structure

© Merck KGaA, Darmstadt, Germany, 2013

All references to Merck refer to Merck KGaA, Darmstadt, Germany.


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